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WNT-1, Human Recombinant

品牌
Sigma-Aldrich
货号
GF175
包装型号
规格纯度
参考价格
4326.77 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intracellular signaling protein, β-catenin. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.
Product Source: E. coli.

特异性

Cross Reactivty
Mouse

应用

Research Category
Stem Cell Research
Research Sub Category
Growth Factors & Receptors

质量

Bioactivity assay: The ED50 was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED50 for this effect is 1.5 - 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.

外形

Product is filtered through a 0.2 micron filter before lyophilization. Product is presented in .

储存及稳定性

Store at -20°C for up to 6 months from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405
NACRESNA.75

产品性质

质量水平100
测定>98% (SDS-PAGE and HPLC)
technique(s)cell culture | stem cell: suitable
杂质<0.1 μg/mg protein endotoxin (<1EU/μg)
UniProt登记号P04628
运输dry ice

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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