产品介绍：
产品说明
生化/生理作用
WIN 18,446 is an orally available bisdichloroacetyldiamine that potently inhibits aldehyde dehydrogenase family 1 (ALDH1) members-catalyzed all-trans retinoic acid (atRA) production (IC50 = 88 nM/human testicular S10 fraction, 102 nM/ALDH1A1, 187 nM/ALDH1A3) via retinal oxidation, efficiently inhibits ALDH1A2 enzymatic activity in a time-dependent manner (kinact = 22.0/h, Ki = 1026 nM). The inhibitory activity of WIN 18,446 against atRA production forms the basis of its in vivo efficacy as a male contraceptive in inhibiting spermatogenesis among mulitple mammalian species and zebrafish.
基本信息
| 经验(实验)分子式 | C12H20Cl4N2O2 |
| 分子量 | 366.11 |
| MDL编号 | MFCD00000841 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | −20℃ |
| SMILES string | O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H312 + H332 - H351 |
| 预防措施声明 | P202 - P261 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313 |
| 危险分类 | Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Carc. 2 |
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
