位置:首页 > 品牌 > Sigma-Aldrich >

Vatalanib dihydrochloride

品牌
Sigma-Aldrich
CAS
212141-51-0
货号
SML2498
规格纯度
≥98% (HPLC)
参考价格
610.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Vatalanib (PTK787, ZK 222584, CGP 79787D, CGP 79787 succinate) is an orally active anilinophthalazine derivative that exerts its anti-angiogenic efficacy by targeting receptor tyrosine kinase (RTK) VEGFR (VEGFR1/2 IC50 = 54/39 nM; IC50 ∼30 nM against 100 ng/mL VEGF-C-induced VEGFR3 autophosphorylation in MEVCs) and, to a less extent, PDGFRβ, c-kit, c-fms (IC50 = 364, 600, 567 nM, respectively) in an ATP-competitive manner with much reduced or no potency toward >90 other kinases. Typical dosing ranges: 0.1-10 μM in cultures, 5 nM-200 μM (zebrafish) and 30-100 mg/kg (mice & rats via po. or ip) in vivo.

基本信息

经验(实验)分子式C20H15ClN4 · 2HCl
分子量419.73
MDL编号MFCD08458963

产品性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性H2O: 2 mg/mL, clear
储存温度2-8℃
SMILES stringClC(C=C1)=CC=C1NC2=NN=C(CC3=CC=NC=C3)C4=CC=CC=C42

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号