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TNF- α Protein, Human Recombinant Animal Free

品牌
Sigma-Aldrich
货号
GF314
规格纯度
Tumor necrosis factor alpha (TNF-α), also known as cachectin & TNFSF1A, is the prototypic ligand of the TNF superfamily. Recombinant animal free human TNF-α is manufactured using all non-animal reagents.
参考价格
4878.21 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Product Source: E. coli
Tumor necrosis factor alpha (TNF-α), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. Recombinant human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.

特异性

Cross Reactivty
Cow, Monkey, Mouse, Rat, Sheep

应用

Research Sub Category
Growth Factors & Receptors
Research Category
Inflammation & Immunology

质量

Bioactivity assay: The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥2 x 107 units/mg.

外形

Recombinant animal free human TNF- α is manufactured using all non-animal reagents
Product is filtered through a 0.2 micron filter before lyophilization.

储存及稳定性

Store at -20°C for up to 6 months from date of receipt.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss32160405

产品性质

质量水平100
重组expressed in E. coli
测定>98% (SDS-PAGE and HPLC)
杂质<0.1 μg/mg protein endotoxin (<1EU/μg)
NCBI登记号NM_000594.2
UniProt登记号P01375
运输dry ice

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3

Sigma-Aldrich

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