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Tim-3 (mouse): FC (human)

品牌
Sigma-Aldrich
货号
SRP8056
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
参考价格
8416.19 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Tim-3 is a type I transmembrane protein. It contains an immunoglobulin and a mucin-like domain in its extracellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. TIM-3 is preferentially expressed on Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. TIM-3 is also expressed on some dendritic cells. The gene encoding this protein is localized on mouse chromosome 11B1.1.

生化/生理作用

The T cell/transmembrane, immunoglobulin and mucin (TIM) family plays a crucial role in regulating immune responses, such as allergy, asthma, transplant tolerance, autoimmunity and also has a control over the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. Tim-3 generates an inhibitory signal resulting in apoptosis of Type 1 T-helper (Th1) and Type 1 CD8+ T (Tc1) cells. It can also mediate phagocytosis of apoptotic cells and cross-presentation of antigen. It functions to inhibit aggressive Th1-mediated auto- and allo-immune responses. Tim-3 pathway blockade by administration of Tim-3: Fc fusion protein accelerates diabetes in non-obese diabetic mice, causes hyperproliferation of Th1 cells and Th1 cytokine release in an experimental autoimmune encephalomyelitis (EAE) model and prevents acquisition of transplantation tolerance induced by costimulation blockade.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute at 100 μg/mL in sterile PBS.

其他说明

The extracellular domain of mouse Tim-3 (aa 21-189) is fused to the N-terminus of the Fc region of human IgG1.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in CHO cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量monomer 45 kDa by calculation
包装pkg of 100 μg
储存条件avoid repeated freeze/thaw cycles
杂质<0.06 EU/μg endotoxin, tested
颜色 white
UniProt登记号Q8VIM0
运输wet ice
储存温度−20℃
Gene Informationmouse ... Havcr2(171285)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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