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Tim-1 (human): FC (human)

品牌
Sigma-Aldrich
货号
SRP8054
规格纯度
recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)
参考价格
8415.68 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

外形

Lyophilized from 0.2 μm-filtered solution in PBS.

重悬

Reconstitute at 100 μg/mL in sterile PBS.

其他说明

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

产品性质

生物来源human
重组expressed in CHO cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量monomer 57 kDa by calculation
包装pkg of 100 μg
储存条件avoid repeated freeze/thaw cycles
杂质<0.06 EU/μg endotoxin, tested
颜色 white
UniProt登记号Q96D42
运输wet ice
储存温度−20℃
Gene Informationhuman ... HAVCR1(26762)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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