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TIGAR-TAT human

品牌
Sigma-Aldrich
货号
SRP3294
规格纯度
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
参考价格
4737.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing transcription factors and other intracellular proteins into primary as well as transformed cells.

生化/生理作用

TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. Recombinant human TIGAR-TAT expressed in E. coli is a 36 kDa protein containing 284 amino-acid residues, including the 271 residues of full-length TIGAR fused to a 13-residue C-terminal peptide containing the TAT transduction domain (GGYGRKKRRQRRR).

外形

Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥95% (HPLC)
≥95% (SDS-PAGE)
形式lyophilized
效能0.1-5.0 μg/mL
分子量 36.0 kDa
包装pkg of 25 μg
杂质<0.1 EU/μg endotoxin, tested
颜色 white
UniProt登记号Q9NQ88
运输wet ice
储存温度−20℃
Gene Informationhuman ... C12ORF5(57103)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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