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SQ109

品牌
Sigma-Aldrich
CAS
502487-67-4
货号
SML1309
规格纯度
≥98% (HPLC)
参考价格
3865.31 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

SQ109 is a 1,2-ethylenediamine, which is related to ethambutol.

应用

SQ109 has been used:

  • as an antitubercular agent to study its interactions with mycobacterial membrane proteins large 3 (MmpL3) binding pocket
  • as a positive control to determine the minimum inhibitory concentration (MIC) of ohmyungsamycins (OMS) A and B against Mycobacterium tuberculosis (Mtb) using the resazurin microtiter assay (REMA) plate method
  • as an inhibitor of MmpL3 to explore the utility of mycobacterial CRISPR interference for validating target gene essentiality and compound mode of action

生化/生理作用

SQ109 exhibits activity against Helicobacter pylori and the fungi Candida albicans. It might also possess anti-bacterial activity.
SQ109 is an antitubercular developed for the treatment of multidrug-resistant tuberculosis (MDR-TB). SQ109 inhibits the activity of MmpL3, a mycolic acid transporter required for incorporation of mycolic acid into the Mycobacterium tuberculosis cell wall.

基本信息

经验(实验)分子式C22H38N2
分子量330.55
PubChem化学物质编号329825775
NACRESNA.77

产品性质

质量水平100
测定≥98% (HPLC)
形式oil
颜色 colorless to yellow
储存温度2-8℃
SMILES stringC/C(CCC=C(C)C)=C\CNCCNC1[C@@H]2C[C@@H]3C[C@H]1C[C@H](C2)C3
InChI1S/C22H38N2/c1-16(2)5-4-6-17(3)7-8-23-9-10-24-22-20-12-18-11-19(14-20)15-21(22)13-18/h5,7,18-24H,4,6,8-15H2,1-3H3/b17-7+
InChI keyJFIBVDBTCDTBRH-REZTVBANSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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