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SMN (1472-1613) GST tag human

品牌
Sigma-Aldrich
货号
SRP6589
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
参考价格
3288.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Tudor domains are small protein structural motifs of ~50 amino acids related to the “Royal family” of methyl readers, which also includes chromo, MBT, PWWP, and Agenet-like domains. Tudor domains occur either alone, in tandem, or with other domains and are found in many proteins that are involved in RNA metabolism, germ cell development, transposon silencing, DNA damage response, histone modification and chromatin remodeling. The tudor domains recognize symmetric methylated arginine or methylated lysine residues. The Survival of Motor Neurons (SMN) protein participates in RNA splicing. The Tudor domain of SMN recognizes and binds methylated Sm proteins, which bind small nuclear RNA. SMN is encoded in humans by two separate genes, SMN1 and SMN2, which differ by one base in exon 7. In motor neuron cells, approximately 90% of the SMN2 transcripts are spliced to exclude exon 7. The SMN2 transcripts without exon 7 are less stable than SMN1 transcripts. Consequently, defects in human SMN1 result in the death of motor neuron cells and spinal muscular atrophy, which is the leading genetic cause of infantile death. This protein product contains the tudor domain region of SMN. The sequence of this region is identical in both the SMN1 and the SMN2 genes.

外形

50 mM Tris-HCl, 150 mM sodium chloride, pH 8.0, containing 20% glycerol.

产品性质

生物来源human
重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式liquid
分子量 42.6 kDa (1472-1613 aa, NT GST Tag)
包装pkg of 20 μg
pkg of 50 μg
UniProt登记号Q16637
运输dry ice
储存温度−70℃
Gene Informationhuman ... SMN1
SMN2(6606)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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