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SMAD3, GST tagged human

品牌
Sigma-Aldrich
CAS
184379-52-0
货号
SRP5132
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
参考价格
4311.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

SMAD3 is a direct mediator of transcriptional activation by the TGFβ receptor. The activity of SMAD3 is regulated by the TGFβ receptors, and SMAD3 is phosphorylated and associated with the ligand-bound receptor complex. TGFβ stimulation leads to phosphorylation and activation of SMAD3, which form a complex with SMAD4 that accumulate in the nucleus and regulate transcription of target genes such as CDK inhibitor. SMAD3 containing a C-terminal truncation acts as a dominant-negative inhibitor of the normal TGFβ response. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2.

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式buffered aqueous glycerol solution
分子量 ~77 kDa
NCBI登记号NM_005902
application(s)cell analysis
运输dry ice
储存温度−70℃
Gene Informationhuman ... SMAD3(4088)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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