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SIRT6, active, His tagged human

品牌
Sigma-Aldrich
CAS
1391452-80-4
货号
SRP5273
规格纯度
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
参考价格
7744.34 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

SIRT6 is a member of the sirtuin family of proteins which are homologs to the yeast Sir2 protein. Sirtuin family contain a sirtuin core domain and are grouped into four classes with SIRT6 being a member of class IV. Human SIRT6 protein is a NAD(+)-dependent histone H3 lysine-9 deacetylase that modulates telomeric chromatin. SIRT6 associates specifically with telomeres and SIRT6 depletion leads to telomere dysfunction with end-to-end chromosomal fusions and premature cellular senescence. SIRT6 -/- mouse cells show that SIRT6 promotes resistance to DNA damage and suppresses genomic instability in association with a role in base excision repair.

外形

Supplied in 50 mM sodium phosphate, pH 7.0, 300 mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.2 mM DTT, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
测定≥70% (SDS-PAGE)
形式buffered aqueous glycerol solution
specific activity96-144 RLU/min·ng
分子量 ~39 kDa
NCBI登记号NM_016539
application(s)cell analysis
运输dry ice
储存温度−70℃
Gene Informationhuman ... SIRT6(51548)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H360D
预防措施声明P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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