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RNA Polymerase II, RPB12 subunit, GST tagged human

品牌
Sigma-Aldrich
货号
SRP2119
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
5245.91 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

POLR2K (RNA polymerase II subunit K) is located on human chromosome 8q22. Rpb12 is the eukaryotic subunit that is also called as ABC10α. Rpb12 is the general subunit of all three eukaryotic RNA polymerases.

生化/生理作用

RPB12 (also called RPB10 ) is shared between all three RNA polymerases and is homologous to the archaeal P subunit of RNA polymerase. Like RPB10, it is essential for yeast cell viability. RPB12 is also a zinc-binding protein with a canonical tetra-coordinating zinc motif but binds zinc in vitro much less efficiently than the RPB10 subunit. It has been shown to interact with both RPB1 and RPB2 in vitro and the human subunit can functionally substitute for its yeast counterpart.
RPB12/RPC10 (RNA polymerase II subunit K) is required for growth in Saccharomyces cerevisiae. The carboxy-terminal domain (CTD) of RNAP II plays a major role in recruiting many of these activities to the transcriptional machinery.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~33 kDa
包装pkg of 10 μg
储存条件avoid repeated freeze/thaw cycles
浓度100 μg/mL
颜色clear colorless
NCBI登记号NM_005034
UniProt登记号P53803
运输dry ice
储存温度−70℃
Gene Informationhuman ... POLR2K(5440)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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