产品说明
免疫原
The epitope recognized by PLA0157 maps to a region between residue 470 and the C-terminus (residue 522) of human stress-activated map kinase interacting protein 1 using the numbering given in entry NP_001006618.1 (GeneID 79109).
外形
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
其他说明
Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 100 |
| 抗体形式 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| 等级 | Powered by Bethyl Laboratories, Inc. |
| species reactivity | human |
| technique(s) | immunohistochemistry: 1:1,000- 1:5,000 immunoprecipitation (IP): 2-5 μg/mg western blot: 1:2,000- 1:10,000 |
| 登记号 | NP_001006618.1 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | rabbit ... Sin1(79109) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | nwg |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
