产品说明
一般描述
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
外形
Solution in PBS.
其他说明
Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG®-tag.
法律信息
FLAG is a registered trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.32 |
产品性质
| 生物来源 | mouse |
| 重组 | expressed in HEK 293 cells |
| 标签 | FLAG® tagged |
| 测定 | >95% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | ~70 kDa by SDS-PAGE |
| 包装 | pkg of 10 μg |
| manufacturer/tradename | sigma-aldrich |
| 储存条件 | avoid repeated freeze/thaw cycles |
| 浓度 | ≥0.2 mg/mL |
| 杂质 | <0.1 EU/μg endotoxin, tested |
| 颜色 | clear |
| UniProt登记号 | P28798 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | mouse ... Grn(14824) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
