产品说明
一般描述
Protein arginine methyltransferase 4 (PRMT4), which is also known as coactivator associated arginine methyltransferase 1 (CARM1), is part of the protein arginine methyltransferase (PRMT) family. The gene encoding this protein is localized on human chromosome 19p13.2.
应用
Study enzyme kinetics, and screen small molecular inhibitors of PRMT4 histone methyltransferase for drug discovery and HTS applications.
生化/生理作用
Protein arginine methyltransferase 4 (PRMT4) methylates arginine residues of histones and other proteins and thus has a role in modulation of gene expression. The protein also methylates histone acetyl transferases. It has been shown to associate with Mi2a, a chromatin remodeler. It also associates with nuclear factor-κB (NF-κB), estrogen receptor and tumor suppressor p53 and is recruited to specific target genes. PRMT4 has a role in pre-mRNA splicing and DNA damage response. The protein has been shown to be upregulated in liver, prostate and breast cancers.
外形
Supplied in a TRIS-buffered solution.
其他说明
200 μL at 400 μM, or 80 nmol. Sold as 80 nmol
基本信息
| NACRES | NA.32 |
产品性质
| 测定 | ≥90% (HPLC) |
| 形式 | aqueous solution |
| 包装 | pkg of 80 nmol |
| 浓度 | 400 μM |
| UniProt登记号 | Q86X55 |
| 运输 | dry ice |
| 储存温度 | −70℃ |
| Gene Information | human ... CARM1(10498) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
