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PFTK1 (CDK14)/CYCLINY, Active

品牌
Sigma-Aldrich
货号
SRP0713
规格纯度
PRECISIO® Kinase, recombinant
参考价格
6051.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Useful for Kinase assay and Western blot.

生化/生理作用

Recombinant human full-length PFTK1 (CDK14) and Cyclin Y (2-end) were co-expressed by Baculovirus in Sf9 insect cells using N-terminal GST tags. PFTK1 is a member of the CDC2 - related protein kinase family which is expressed primarily in the postnatal and adult nervous system (1). PFTK1 is expressed at high levels in brain, pancreas, kidney, heart, testis, and ovary. PFTK1 amino acid residue ser119 is required for its interaction with all four 14-3-3 isoforms, while ser120 may contribute slightly to PFTK1 binding (2). PFTK1 acts as a cyclin-dependent kinase that regulates cell cycle progression and cell proliferation. Overexpression of PFTK1 predicts resistance to chemotherapy in patients with oesophageal squamous cell carcinoma.

重悬

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

产品性质

重组expressed in baculovirus infected Sf9 cells
测定70-95% (SDS-PAGE)
形式frozen liquid
specific activity2.0-3.5 nmol/min·mg (radiometric)
分子量 ~64 kDa (Cyclin Y)
~72 kDa (PFTK1 (CDK14))
浓度0.1 μg/μL
登记号NM_012395
NM_145012
运输dry ice
储存温度−70℃
Gene Informationhuman ... CCNY(219771), CDK14(5218)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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