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NT-1/BCSF-3 human

品牌
Sigma-Aldrich
货号
SRP3127
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
参考价格
4825.22 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3), also known as cardiotrophin-like cytokine factor 1 (CLCF1), is encoded by the gene mapped to human chromosome 11q13.2. The encoded protein is a new member of the gp130 cytokine family. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

生化/生理作用

Novel neurotrophin-1/B-cell stimulating factor-3 (NNT-1/BSF-3) has neurotrophic and B cell stimulatory effects.In addition, it is also implicated in neuroimmunoendocrine modulation of corticotroph function. BSF-3 helps in the embryonic development and differentiation of motor, sensory and autonomic neurons. It also facilitates the bone formation during development and in the ongoing remodeling of endochondral bone. The encoded protein binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member b (LIFR-b). This ligand and receptor interaction further induces downstream signaling events and activates Janus kinase 1 (JAK1)-signal transducer and activator of transcription protein 3 (STAT3) signaling pathway. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM.

序列

MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF

外形

Lyophilized with no additives.

重悬

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8℃ for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20℃ to -80℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥98% (HPLC)
≥98% (SDS-PAGE)
形式lyophilized
分子量 22.4 kDa
包装pkg of 10 μg
technique(s)cell culture | mammalian: suitable
杂质<0.1 EU/μg endotoxin, tested
颜色 white to off-white
UniProt登记号Q9UBD9
运输wet ice
储存温度−20℃
Gene Informationhuman ... CLCF1(23529)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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