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mTOR/Raptor/MLST8 human

品牌
Sigma-Aldrich
货号
SRP0364
规格纯度
recombinant, expressed in baculovirus infected Sf9 cells, ≥50% (SDS-PAGE)
参考价格
8365.25 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

This product (recombinant mTOR/Raptor/MLST8) is a complex of human mechanistic target of rapamycin (mTOR), also known as FRAP1 (GenBank Accession No. NM_004958), amino acids 1362-end with N-terminal FLAG-tag, MW = 137 kDa; human MTOR associated protein, LST8 homolog (MLST8) (GenBank Accession No. NM_022372) amino acids 2-326 (end) with N-terminal His-tag, MW = 37 kDa and human regulatory associated protein of MTOR complex 1 (Raptor) (GenBank Accession No. NM_020761) amino acids 2-1335 (end) with N-terminal His-tag, MW=150 kDa, co-expressed in a Baculovirus-infected Sf9 cell expression system.

应用

Recombinant mTOR/Raptor/MLST8 has been used in in vitro caspase reactions.

生化/生理作用

Mechanistic target of rapamycin (mTOR) modulates cell growth and division by integrating nutrient and mitogen signals. It also modulates the functions of antigen-presenting cells, like dendritic cells and activates T-cells. mTOR is also involved in innate and adaptive immunity. MTOR associated protein, LST8 homolog (MLST8) is a subunit of both the mTOR complex 1 and 2 (mTORC1 and 2). It is crucial for the activation of the mTOR kinase and is a regulator of mTOR pathways. Regulatory associated protein of MTOR complex 1 (RAPTOR) has an important role in modulating cell growth and in energy homeostasis as a scaffolding protein. It takes part in recruiting substrates of mechanistic target of rapamycin (mTOR) to the rapamycin-sensitive mTOR complex 1 (mTORC1). RAPTOR also associates with proteins involved in the pathway and aids in phosphorylating them.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
测定≥50% (SDS-PAGE)
形式aqueous solution
分子量 137 kDa (mTOR)
150 kDa (Raptor)
37 kDa (MLST8)
包装pkg of 10 μg
NCBI登记号NM_004958 (mTOR)
NM_020761 (Raptor)
NM_022372 (MLST8)
运输dry ice
储存温度−70℃
Gene Informationhuman ... MLST8(64223), MTOR(2475), RPTOR(57521)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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