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Monoclonal Anti-SPA17 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB1403268
规格纯度
clone 3B6, purified immunoglobulin, buffered aqueous solution
参考价格
5001.78 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Sperm autoantigenic protein 17 (SPA17) gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22. SPA17 gene is located on human chromosome 11q24.2. This antigenic protein contains 151 amino acids and has a molecular weight of 17.4 kDa. This protein is highly expressed in testis and in somatic tissues.

免疫原

SPA17 (NP_059121, 51 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
EKTNFDPAEWGSKVEDRFYNNHAFEEQEPPEKSDPKQEESQISGKEEETSVTILDSSEEDKEKEEVAAVKIQAAFRGHIAREEAKKMKTNSLQNEEKEE

生化/生理作用

Sperm autoantigenic protein 17 (SPA17) functions as a testis specific antigen. It also mediates signal transduction, protein synthesis and unregulated growth in proliferating and neoplastic cells. Overexpression of this protein decreases the resistance of epithelial ovarian carcinoma to chemotherapy. It regulates protein kinase A-independent AKAP (A-kinase anchoring proteins) complex in both germinal and somatic cells.160 The gene is associated with rheumatoid arthritis (RA).

外形

Solution in phosphate buffered saline, pH 7.4

基本信息

NACRESNA.41

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆3B6, monoclonal
形式buffered aqueous solution
分子量antigen ~37 kDa
species reactivityhuman
technique(s)capture ELISA: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
同位素/亚型IgG2aκ
NCBI登记号NM_017425
UniProt登记号Q15506
运输dry ice
储存温度−20℃
Gene Informationhuman ... SPA17(53340)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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