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Monoclonal Anti-RBBP8 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB2702168
包装型号
规格纯度
参考价格
6262.8 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

免疫原

Human CtIP

应用

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IP: Assay-dependent dilution, WB: 1:500-1:1000 (3% Milk/TBST overnight), ChIP assay: Assay-dependent dilution, PLA: Assay-dependent dilution. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生化/生理作用

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disruppted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Phosphate-buffered saline, pH 7.4, containing no preservatives

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆19E8
monoclonal
形式liquid
分子量 125 kDa
species reactivityhuman, mouse
浓度1.3 mg/mL
technique(s)ChIP: suitable
immunocytochemistry: 1:100-1:1000
immunofluorescence: suitable
immunoprecipitation (IP): suitable
proximity ligation assay: suitable
western blot: 1:500-1:1000
同位素/亚型IgG
UniProt登记号Q99708
运输wet ice
储存温度−20℃
Gene Informationhuman ... RBBP8(5932)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

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