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Monoclonal Anti-PLEKHA7 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200643
规格纯度
clone PLK7, purified from hybridoma cell culture
参考价格
6092.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-PLEKHA7 (mouse IgG2a isotype) is derived from the hybridoma PLK7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a sequence at the N-terminal region of human PLEKHA7, conjugated to KLH. PLEKHA7 contains WW (rsp5-domain), PH (pleckstrin homology), and CC (coiled-coil) domains.
PLEKHA7 (Pleckstrin homology domain containing, family A member 7) is an adherens junction protein localized at the adherens junctions in colonic epithelial cells.

免疫原

synthetic peptide corresponding to a sequence at the N-terminal region of human PLEKHA7

应用

Monoclonal Anti-PLEKHA7 antibody has been used in

  • immunoblotting
  • immunocytochemistry
  • flow cytometry

生化/生理作用

PLEKHA7 (Pleckstrin homology domain containing, family A member 7) functions as a cytoplasmic component of the epithelial adherens junction belt, with a subcellular localization and tissue distribution and connects E-cadherin-p120 ctn complex to the microtubule cytoskeleton. It has been reported that PLEKHA7 acts as zonula adherens (ZA) component, identifies Nezha, which further binds to microtubules (MTs) of the cytoskeleton, and forms a protein complex during cytoskeleton assembly.
Overexpression of PLEKHA7 was reported to be common in invasive lobular carcinomas (ILCs) and hence PLEKHA7 could serve as a molecular marker to differentiate ILCs from invasive ductal carcinomas (IDCs).

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平200
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆PLK7, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度~1 mg/mL
technique(s)flow cytometry: 2-4 μg/test using NCI-H1299 cells
immunoblotting: suitable
immunocytochemistry: 0.25-0.5 μg/mL using human CaCo2 cells
同位素/亚型IgG2a
UniProt登记号Q6IQ23
运输dry ice
储存温度−20℃
Gene Informationhuman ... PLEKHA7(144100)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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