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Monoclonal Anti-MASTL antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200649
规格纯度
clone 2C8/D11, purified from hybridoma cell culture
参考价格
6162.13 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-MASTL (mouse IgG2b isotype) is derived from the hybridoma 2C8/D11 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a fusion protein. Microtubule-Associated Serine/Threonine kinase-Like (MASTL), also known as GREATWALL (GWL) in Drosophila and Xenopus is localized to the nucleus but, during M-phase it is activated and re-localized to the centrosomes.

免疫原

immunized with a fusion protein of 250aa polypeptide from the region that divides the kinase domain of mouse MASTL

应用

Monoclonal Anti-MASTL antibody produced in mouse may be used in various immunochemical techniques including immunoblotting, flow cytometry and immunofluorescence.

生化/生理作用

Microtubule-associated serine/Threonine kinase-Like (MASTL) acts as a cell cycle marker of M phase. It has an ability to regulate mitosis entry, anaphase and cytokinesis. In Drosophila MASTL (Greatwall) was initially identified as a kinase essential for chromosome condensation. MASTL enhances cyclin B1-Cdk1-dependent mitotic phosphorylation events. Furthermore, MASTL is also an inhibitor of the tumor suppressor protein Phosphatase 2A (PP2A), and thus maintains the equilibrium between cyclin B-Cdk1 and PP2A. A missense mutation in the MASTL gene leads to the development of autosomal dominant inherited thrombocytopenia.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平200
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆2C8/D11, monoclonal
形式buffered aqueous solution
分子量 ~100 kDa
species reactivitymonkey, human
浓度~1 mg/mL
technique(s)flow cytometry: 10-20 μg/test using using human HeLa cells.
immunoblotting: 1-2 μg/mL using whole extracts of human HeLa cells.
immunofluorescence: 10-20 μg/mL using using human HeLa cells.
同位素/亚型IgG2b
UniProt登记号Q96GX5
运输dry ice
储存温度−20℃
Gene Informationmouse ... Mastl(67121)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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