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Monoclonal Anti-KRT18-Biotin antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700671
规格纯度
clone DC-10, purified immunoglobulin, buffered aqueous solution
参考价格
4053.29 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Keratin 18 (KRT 18) or cytokeratin 18 (CK18) encodes the type I intermediate filament chain keratin 18. The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. In human chromosome, the gene KRT18 is localized on 12q13.13.

免疫原

Human breast carcinoma cell line PMC-42

应用

The reagent is designed for Flow Cytometry. Suggested working dilution is 1:500. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Keratin 18 (KRT18/CK18) pairs with CK8 to form the intermediate filaments and maintain the integrity in hepatocytes. CK18 associates with histone H3 in the progression of hepatocellular carcinoma (HCC). Disorganization or altered levels of CK18 is related to plectin deficiency in HCC. K18 may be a marker for liver diseases. K18 is present in Mallory bodies and is elevated in alcoholic cirrhosis and alcoholic hepatitis. K18 expression is modulated by interleukin 6 (IL-6). K18 interacts with desmosomal protein/ E-cadherin and promotes cell adhesion. CK18 is cleaved by caspases during apoptosis and released into blood as caspase cleaved cytokeratin-18 (CCCK18).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

基本信息

NACRESNA.41

产品性质

生物来源mouse
偶联物biotin conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆DC-10, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG1
NCBI登记号NM_000224.2
UniProt登记号P05783
运输wet ice
储存温度2-8℃
Gene Informationhuman ... KRT18(3875)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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