产品说明
一般描述
The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons.
特异性
Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1.
免疫原
Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975.
生化/生理作用
Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans.
特点和优势
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外形
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | S4-11, monoclonal |
| 形式 | buffered aqueous glycerol solution |
| 分子量 | antigen predicted mol wt 105-125 kDa |
| species reactivity | rat, monkey, human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| 同位素/亚型 | IgG1 |
| NCBI登记号 | NP_037318 |
| UniProt登记号 | Q14721 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | rat ... Kcnb1(25736) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
