产品说明
一般描述
Ephrin type-B receptor 6 (EPHB6) belongs to Ephrin receptors family, which make up the largest subgroup of the receptor tyrosine kinase (RTK) family. They are divided into the ephrin-A (EFNA) and ephrin-B (EFNB) based on their structures, and sequence of their extracellular domain sequences. EFNA is anchored to the membrane by a glycosylphosphatidylinositol linkage. EFNB, which are transmembrane proteins. They have varying affinities for binding ephrin-A and ephrin-B ligands. EPHB6 gene is mapped to human chromosome 7q34. EPHB6 is majorly expressed in thymus and nervous system. It has a cytoplasmic kinase domain.
免疫原
EPHB6 (NP_004436, 23 a.a. ~ 122 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
DTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEE
应用
Monoclonal Anti-EPHB6 antibody produced in mouse has been used in western blotting.
生化/生理作用
EPHB6 modulates T cell response by inhibiting the c-Jun N-terminal kinase (JNK) pathway. Phosphorylation of tyrosine residue in Ephrin type-B receptor 6 (EPHB6) is crucial for de-adhesion functionality. EPHB6 devoid of kinase domain favors adhesion and cell migration. Malignant glioma cells show expression of the alternative spliced EphB6 variant. EPHB6 is overexpressed in breast cancer cell lines and prostate cancer. It inhibits tumor invasion. Expression of EphB6 suppresses tumor growth in neuroblastoma.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 5D8, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~37 kDa |
| species reactivity | mouse, human, rat |
| technique(s) | capture ELISA: suitable immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable indirect ELISA: suitable western blot: 1-5 μg/mL |
| 同位素/亚型 | IgG2aκ |
| NCBI登记号 | NM_004445 |
| UniProt登记号 | O15197 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... EPHB6(2051) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
