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Monoclonal Anti-EEF1A1 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4200657
规格纯度
clone EF48, purified from hybridoma cell culture
参考价格
6732.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Monoclonal Anti-EEF1A1 (mouse IgG2b isotype) is derived from the hybridoma EF48 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Eukaryotic elongation factor 1 A-1 (EEF1A1), also known as EF-l α is a GTP-binding protein. EEF1A1 is one of the most abundant cytoplasmic proteins and is ubiquitously expressed except in neurons and muscle.
Eukaryotic translation elongation factor 1 α 1 (EEF1A1) is a cellular protein which is part of the eukaryotic elongation factor 1 (eEF1) complex. The gene encoding it is localized on human chromosome 6q14.1.

免疫原

a synthetic peptide corresponding to an internal sequence of human EEF1A1

应用

Monoclonal Anti-EEF1A1 antibody produced in mouse has been used in immunoblotting and immunofluorescence.

生化/生理作用

Eukaryotic elongation factor 1 A-1 (EEF1A1) is involved in proper codon-anticodon binding interactions between mRNAs and tRNAs at the tRNA acceptor site of the ribosome. EEF1A also plays a translation-independent role in embryogenesis, senescence, oncogenic transformation, cell proliferation, apoptosis, cytoskeletal organization and protein degradation. Overexpression of EEF1A1 has been observed in various tumors of the pancreas, colon, breast, lung, and stomach.
Eukaryotic translation elongation factor 1 α 1 (EEF1A1) binds to aminoacetylated tRNAs and delivers them to the elongating ribosome during protein synthesis. It aids in the association of the eukaryotic elongation factor 1 (eEF1) complex with the HIV-1 (human immunodeficiency virus-1) reverse transcription complex. EEF1A1 also associates with genomic RNA secondary structures of RNA viruses and helps in their replication.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品性质

质量水平200
生物来源mouse
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆EF48
形式buffered aqueous solution
species reactivitybovine, rat, mouse, canine, monkey, human
浓度~1 mg/mL
technique(s)immunoblotting: 1-2 μg/mL using whole extracts of HEK-293T cells.
immunofluorescence: 0.5-1 μg/mL using SW-620 cells.
同位素/亚型IgG2b
UniProt登记号P68104
运输dry ice
储存温度−20℃
Gene Informationhuman ... EEF1A1(1915)
mouse ... Eef1a1(13627)
rat ... Eef1a1(171361)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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