产品说明
一般描述
Integrin subunit α M (ITGAM), also known as cluster of differentiation 11 antigen-like family member B (CD11b), belongs to integrin α chain family. The rat monoclonal antibody M1/70 detects CD11b (integrin αM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions. In human chromosome, the gene ITGAM is localized on 16p11.2.
免疫原
B10 mouse spleen cells enriched for T cells
应用
The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. Monoclonal Anti-CD11b-FITC antibody produced in rat has been used in fluorescence-activated cell sorting (FACS) analysis.
生化/生理作用
Integrin subunit α M (ITGAM) combines with b2 chain (ITGB2) and forms leukocyte integrin, which is commonly referred as macrophage 1 antigen (MAC-1) or complement receptor 3 (CR3), which is essential for adherence of neutrophils and monocytes to stimulated endothelium. ITGAM is a receptor for the degradation product of complement C3 degradation product (iC3b), intracellular adhesion molecule 1 (ICAM1) and fibrinogen. ITGAM participates in adhesion and phagocytosis. Polymorphism in ITGAM is associated with autoimmune diseases like systemic lupus erythematosus. Single nucleotide polymorphism (SNP) in ITGAM is also related to discoid lupus erythematosus (DLE) and systemic scleroderma. ITGAM is implicated in the regulation of acute myeloid leukemia.
特点和优势
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外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.44 |
产品性质
| 质量水平 | 100 |
| 生物来源 | rat |
| 偶联物 | FITC conjugate |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | M1/70, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | nonhuman primates, human, mouse |
| 浓度 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgG2b |
| NCBI登记号 | NM_001082960.1 |
| UniProt登记号 | P11215 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | mouse ... Itgam(16409) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
