位置:首页 > 品牌 > Sigma-Aldrich >

Monoclonal Anti-CD11b-FITC antibody produced in rat

品牌
Sigma-Aldrich
货号
SAB4700582
规格纯度
clone M1/70, purified immunoglobulin, buffered aqueous solution
参考价格
4172.21 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Integrin subunit α M (ITGAM), also known as cluster of differentiation 11 antigen-like family member B (CD11b), belongs to integrin α chain family. The rat monoclonal antibody M1/70 detects CD11b (integrin αM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions. In human chromosome, the gene ITGAM is localized on 16p11.2.

免疫原

B10 mouse spleen cells enriched for T cells

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution is 1 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator. Monoclonal Anti-CD11b-FITC antibody produced in rat has been used in fluorescence-activated cell sorting (FACS) analysis.

生化/生理作用

Integrin subunit α M (ITGAM) combines with b2 chain (ITGB2) and forms leukocyte integrin, which is commonly referred as macrophage 1 antigen (MAC-1) or complement receptor 3 (CR3), which is essential for adherence of neutrophils and monocytes to stimulated endothelium. ITGAM is a receptor for the degradation product of complement C3 degradation product (iC3b), intracellular adhesion molecule 1 (ICAM1) and fibrinogen. ITGAM participates in adhesion and phagocytosis. Polymorphism in ITGAM is associated with autoimmune diseases like systemic lupus erythematosus. Single nucleotide polymorphism (SNP) in ITGAM is also related to discoid lupus erythematosus (DLE) and systemic scleroderma. ITGAM is implicated in the regulation of acute myeloid leukemia.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.44

产品性质

质量水平100
生物来源rat
偶联物FITC conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆M1/70, monoclonal
形式buffered aqueous solution
species reactivitynonhuman primates, human, mouse
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG2b
NCBI登记号NM_001082960.1
UniProt登记号P11215
运输wet ice
储存温度2-8℃
Gene Informationmouse ... Itgam(16409)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号