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Monoclonal Anti-CD18, low endotoxin antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700399
规格纯度
clone MEM-148, purified immunoglobulin, buffered aqueous solution
参考价格
3548.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

ITGB2 (integrin β2) encodes common β-chain of the β2 integrin family, known as cluster of differentiation 18 (CD18). CD18 associates non-covalently with three different α subunits CD11a, CD11b, CD11c and forms three different heterodimers like lymphocyte function associated antigen-1 (LAD-1), macrophage antigen 1 (Mac-1), and p150,95 respectively. CD18 is primarily expressed in blood. The antibody MEM-148 recognizes an epitope on CD18 which is essentially inaccessible in intact integrin molecules on resting leukocytes, but is exposed on high-affinity state of LFA-1 or on unassociated CD18. CD18 (integrin beta2 subunit; beta2 integrin) is a 90-95 kDa type I transmembrane protein expressed on all leukocytes. In human chromosome, the gene CD18 is localized on 21q22.3.

免疫原

Peripheral blood mononuclear cells

应用

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 8 ug/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

生化/生理作用

Cluster of differentiation (CD18) is involved in adhesion of leukocytes to the endothelium and its migration to the site of inflammation. Lower expression of CD18 is critical because of its involvement in all the heterodimeric complex and controls the expression of α subunit. CD18 is a part of intracellular signalling molecule, signals through phosphatidylinositol 3 kinase (PI3K) and tyrosine kinase. Mutations in ITGB2 causes autosomal recessive leukocyte adhesion deficiency type 1 disorder, characterized by frequent bacterial and fungal infections. Polymorphism in ITGB2 is associated with chronic lymphocytic leukemia (CLL). Mutations in CD18 causes Hirschsprung′s disease (HSCR)-associated enterocolitis (HAEC) and chronic colitis. ITGB2 is upregulated in atherosclerotic plaque.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MEM-148, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG1
NCBI登记号NM_000211.3
UniProt登记号P05107
运输wet ice
储存温度2-8℃
Gene Informationhuman ... ITGB2(3689)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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