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Monoclonal Anti-CD36-FITC antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700168
规格纯度
clone CB38, purified immunoglobulin, buffered aqueous solution
参考价格
4558.24 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Cluster of differentiation 36 (CD36) is an 88 kDa membrane transporter glycoprotein. It is also known as platelet glycoprotein IV or IIIb. CD36 is a class B scavenger receptor expressed in platelets, endothelial cells, adipocytes, skeletal muscle cells and monocytes/macrophages. In human chromosome, the gene CD36 is localized on 7q21.11. CD36 (fatty acid translocase, FAT) is an 85-113 kDa ditopic glycosylated protein that belongs to the class B family of scavenger receptors. CD36 is expressed by most resting marginal zone B cells but not follicular and B1 B cells, and it is rapidly induced on Follicular B cells in vitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, but modulates both primary and secondary antibody response. Similarly to glucose transporter GLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cell stimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chain fatty acids.

特异性

The antibody CB38 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoprotein expressed on platelets, macrophages, endothelial cells, early erythroid cells and megakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibody OKM5.

免疫原

Human myeloid cells

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 4 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (0.4 mL) is sufficient for 100 tests.

生化/生理作用

Cluster of differentiation 36 (CD36) is a receptor for various ligands and act as a signalling molecule. CD36 facilitates the uptake of fatty acids, cholesterol, cholesteryl esters, low and high density lipoproteins. CD36 is involved in fatty acid metabolism. Polymorphism associated with CD36 increases the free fatty acid levels in plasma leading to cardiovascular disease, and hypertension. Polymorphism in CD36 causes type 2 diabetes mellitus. CD36 is a high affinity receptor, which aids in dietary fat perception in the tongue. CD36 along with Toll like receptors (TLRs) aids in internalization of Plasmodium falciparum parasitized erythrocytes. Mutations leading to deficiency of CD36 increases the severity of malaria. CD36 is an inhibitor of lung cancer and the hypermethylation of CD36 leads to cancer progression. CD36, a receptor for thrombospondin. regulates ovarian angiogenesis. High expression of CD36 is implicated in polycystic ovarian syndrome (PCOS).

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.44

产品性质

质量水平100
生物来源mouse
偶联物FITC conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆CB38, monoclonal
形式buffered aqueous solution
species reactivityhuman
technique(s)flow cytometry: suitable
同位素/亚型IgG1
NCBI登记号NM_000072.3
UniProt登记号P16671
运输wet ice
储存温度2-8℃
Gene Informationhuman ... CD36(948)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

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