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Monoclonal Anti-CD19-Biotin antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700111
规格纯度
clone 4G7, purified immunoglobulin, buffered aqueous solution
参考价格
4053.29 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CD19 is transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.

特异性

The antibody 4G7 reacts with CD19 (B4), a 95 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.

免疫原

Human CCL (chronic lymphocytic leukemia) cells

应用

The reagent is designed for Flow Cytometry analysis. working concentrations should be determined by the investigator.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物biotin conjugate
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆4G7, monoclonal
形式buffered aqueous solution
species reactivityhuman
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG1
NCBI登记号NM_001178098.1
UniProt登记号P15391
运输wet ice
储存温度2-8℃
Gene Informationhuman ... CD19(930)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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