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Monoclonal Anti-CD20-APC antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700115
规格纯度
clone 2H7, purified immunoglobulin, buffered aqueous solution
参考价格
5670.5 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intesity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR amd CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment.

特异性

The antibody 2H7 reacts with CD20 (Bp35), a 33-37 kDa non-glycosylated membrane receptor with four transmembrane domains, expressed on B lymphocytes (it is lost on plasma cells), follicular dendritic cells, and at low levels on peripheral blood T lymphocytes.

免疫原

Human tonsillar B cells

应用

The reagent is designed for Flow Cytometry analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (1 mL) is sufficient for 100 tests.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物 (Conjugation - APC)
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆2H7, monoclonal
形式buffered aqueous solution
species reactivityhuman, nonhuman primates
technique(s)flow cytometry: suitable using human blood cells using 10 μL reagent/100 μL of sample
同位素/亚型IgG2a
NCBI登记号NM_021950.3
UniProt登记号P11836
运输wet ice
储存温度2-8℃
Gene Informationhuman ... MS4A1(931)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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