位置:首页 > 品牌 > Sigma-Aldrich >

Monoclonal Anti-CD105 antibody produced in mouse

品牌
Sigma-Aldrich
货号
SAB4700262
规格纯度
clone MEM-229, purified immunoglobulin, buffered aqueous solution
参考价格
3548.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

CD105, also known as endoglin (ENG) gene is mapped to human chromosome 9q34.11. The gene codes for a homodimeric transmembrane coreceptor containing disulfide-linked subunits of 95kDa. The encoded protein is mainly expressed on human pre-erythroblasts, macrophages, leukemic cells of the lymphoid and myeloid lineages. It is also present at higher levels on syncytiotrophoblasts of term placenta and vascular endothelial cells.
The antibody MEM-229 recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.

免疫原

Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Flow cytometry/Cell sorting (1 paper)

生化/生理作用

CD105/ endoglin (ENG) acts as an accessory receptor within transforming growth factor (TGF)-β signalling pathway. It is implicated in the regulation of TGF-β-dependent cellular responses. The protein expressed in endothelial cells plays a vital role in angiogenesis and tumour progression. CD105 functions as a potential target of epigenetic silencing in lung cancer. Deletion of the gene leads to hereditary hemorrhagic telangiectasia. In addition, mutations in the gene is also associated with various cardiovascular anomalies and different types of cancers.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRESNA.41

产品性质

质量水平100
生物来源mouse
偶联物unconjugated
抗体形式purified immunoglobulin
antibody product typeprimary antibodies
克隆MEM-229, monoclonal
形式buffered aqueous solution
species reactivityhuman, pig
浓度1 mg/mL
technique(s)flow cytometry: suitable
同位素/亚型IgG2a
NCBI登记号NM_000118.2
UniProt登记号P17813
运输wet ice
储存温度2-8℃
Gene Informationhuman ... ENG(2022)

安全信息

储存分类代码12 - Non Combustible Liquids
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号