产品说明
一般描述
The antibody MEM-158 reacts with CD15, a cell membrane molecule 3-fucosyl-N-acetyllactosamine (3-FAL) strongly expressed on granulocytes, monocytes, macrophages, mast cells; it is also present on Langerhans cells and some myeloid precursors cells.
Cluster of differentiation 15 (CD15), also known as fucosyltransferase 4 (FUT4)/ Lewis x blood group antigen, is encoded by the gene mapped to long arm of human chromosome 11q21. It is ubiquitously expressed in various tissues such as gastrointestinal tract, brain and leukocytes.
免疫原
Human granulocytes
应用
The reagent is designed for Flow Cytometry analysis using 10 μL reagent / 100 μL of sample.
生化/生理作用
Cluster of differentiation 15 (CD15)/fucosyltransferase 4 catalyzes the synthesis of Lex on the surface of the proliferating cells, in organ buds progressing in mesenchyma, during human embryogenesis. Overexpression of the gene has been associated with development of various type of cancers such as colon cancer, pancreatic cancer, gastric cancer and lung adenocarcinoma. siRNAs of FUT1/4 can be used as a potent therapeutic agent in human LeY-expressing cancers.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | MEM-158, monoclonal |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 浓度 | 1 mg/mL |
| technique(s) | flow cytometry: suitable |
| 同位素/亚型 | IgM |
| NCBI登记号 | NM_002033.3 |
| UniProt登记号 | P22083 |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| Gene Information | human ... FUT4(2526) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
