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MLK4, Active

品牌
Sigma-Aldrich
货号
SRP0725
规格纯度
PRECISIO® Kinase, recombinant
参考价格
5177.2 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Useful for kinase assay and Western blot.

生化/生理作用

Recombinant human MLK4 (114-420) was expressed by Baculovirus in Sf9 insect cells using an N-terminal GST tag. MLK4 or mixed lineage kinase 4 belongs to the superfamily of MAP kinase kinase kinases (MAP3K1) which contain both ser/thr and tyr kinases activity in their catalytic domains. The structure of this kinase family incorporates an N-terminal Src homology (SH3) domain, followed by the kinase domain, a leucine zipper region, and a CDC42 /RAC -interactive binding (CRIB) motif, but divergent C-terminal regions. MLK4 is highly expressed in kidney and pancreas (1). MLK4 is a negative regulator of TLR4 (2).

重悬

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

产品性质

重组expressed in baculovirus infected Sf9 cells
测定70-95% (SDS-PAGE)
形式frozen liquid
specific activity15-25 nmol/min·mg (radiometric)
分子量 ~61 kDa
浓度0.1 μg/μL
登记号NM_032435
运输dry ice
储存温度−70℃
Gene Informationhuman ... MLK4(84451)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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