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MDM2, HIS tagged human

MDM2, HIS标记 人

品牌
Sigma-Aldrich
货号
SRP2095
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution
参考价格
6049.01 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Originally discovered as one of three genes amplified on double minute chromosomes in a tumorigenic derivative of NIH 3T3 cells, MDM2 was later shown to possess oncogenic potential when overexpressed. High-level expression of MDM2 has also been shown to confer tumorigenic potential upon nontransformed rodent fibroblasts in athymic nude mice. MDM2 can immortalize rat embryo fibroblasts and can cooperate with activated RAS to transform these cells. Elevated levels of MDM2 protein have been found in a variety of human tumors, most notably in soft tissue sarcomas where up to 30% of primary tumors contain multiple copies of the MDM2 gene. One mechanism by which MDM2 overexpression promotes tumor development is through its ability to bind to the p53 tumor suppressor, thereby blocking the transactivation, cell cycle arrest, and apoptotic functions of p53. MDM2 can inhibit p53 activity in a number of ways including preventing p53 from recruiting TAFs, promoting nuclear export, inhibiting p53 acetylation, and perhaps most importantly by virtue of its function as an E3 ubiquitin ligase with specificity for, among others, p53. In addition to regulating p53 levels by targeting p53 for proteasomal degradation MDM2 also transfers ubiquitin to itself, MDMX, the ß2 adrenergic receptor, glucocorticoid receptor, TIP60, and PCAF.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
标签8-His tagged (C-terminus. )
测定≥80% (SDS-PAGE)
形式buffered aqueous solution
frozen liquid
分子量 ~57.8 kDa
包装pkg of 10 μg
浓度350 μg/mL
颜色clear colorless
NCBI登记号NM_002392
UniProt登记号Q00987
运输dry ice
储存温度−70℃
Gene Informationhuman ... MDM2(4193)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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