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Manidipine hydrochloride

品牌
Sigma-Aldrich
货号
SML2425
规格纯度
≥98% (HPLC)
参考价格
892.18 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Manidipine is a dihydropyridine class calcium channel blocker (CCB) that exerits its antihypertensive activity via targeting both L-type and T-type calcium channels. In contrary to other dihydropyridines and non-dihydropyridines that mainly act as L-type CCBs, Manidipine diminishes glomerular pressure and, consequently, albumin excretion via its action against T-type channels of efferent arterioles in addition to promoting afferent arteriole dilation by blocking L-type channels. Clinically, Manidipine is as effective in lowering blood pressure as other dihydropyridines, while only Manidipine significantly reduces albuminuria and insulin resistance with less adverse effects. In obese and hypertensive individuals, Manidipine is more effective than Lercanidipine in reducing insulin resistance, while Nifedipine treatment is reported to increase insulin desensitisation.

基本信息

经验(实验)分子式C35H38N4O6 · xHCl
分子量610.70 (free base basis)
MDL编号MFCD00871291

产品性质

测定≥98% (HPLC)
形式powder
储存条件desiccated
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度2-8℃

安全信息

象形图GHS06
警示用语:Danger
危险声明H301 - H336
预防措施声明P261 - P264 - P301 + P310 + P330 - P304 + P340 + P312 - P403 + P233 - P501
危险分类Acute Tox. 3 Oral - STOT SE 3
靶器官Central nervous system
储存分类代码6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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