产品说明
特点和优势
MAL-dPEG®4-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG® spacer arm and an amine-reactive active ester on the other end. The number following the dPEG® refers to the exact number of spacer units present in the spacer arm. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG® spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG® spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.
法律信息
Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign
基本信息
| 经验(实验)分子式 | C24H28F4N2O9 |
| 分子量 | 564.48 |
| MDL编号 | MFCD28505515 |
| PubChem化学物质编号 | 329823940 |
产品性质
| 测定 | >90% |
| 形式 | solid or viscous liquid |
| reaction suitability | reagent type: cross-linking reagent reactivity: amine reactive reagent type: cross-linking reagent reactivity: thiol reactive |
| 聚合物结构设计 | shape: linear functionality: heterobifunctional |
| 运输 | ambient |
| 储存温度 | −20℃ |
| SMILES string | O=C(NCCOCCOCCOCCOCCC(OC1=C(F)C(F)=CC(F)=C1F)=O)CCN2C(C=CC2=O)=O |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
