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LXR, α isoform, N-terminal region (1-182), GST tagged β human

LXR, α isoform, N-terminal region (1-182), GST tagged β human

品牌
Sigma-Aldrich
货号
SRP2133
规格纯度
recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
参考价格
4949.94 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRα and LXRβ. LXRα is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRβ expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRα is thought to play a major role in the control of cholesterol catabolism by stimulating the expression of cholesterol 7-α-hydroxylase (CYP7A1), the rate limiting enzyme of bile acid synthesis.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥80% (SDS-PAGE)
形式frozen liquid
分子量 ~47.5 kDa
包装pkg of 10 μg
浓度300 μg/mL
颜色clear colorless
NCBI登记号NM_005693
UniProt登记号Q13133
运输dry ice
储存温度−70℃
Gene Informationhuman ... NR1H3(10062)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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