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LXR β isoform, ligand binding domain (211-461), GST tagged human

品牌
Sigma-Aldrich
货号
SRP2138
规格纯度
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
参考价格
4949.94 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXRa and LXRb. LXRb is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXRa expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). LXRb expressed in livers of LXRa knockout mice does not compensate for the loss of LXRa. In addition, LXRb, but not LXRa, is also able to activate transcription of a reporter gene, which contains a specific direct repeat separated by 1 bp (DR1) element in the promoter, suggesting that LXRb may have different biological functions.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
重组expressed in E. coli
测定≥70% (SDS-PAGE)
形式frozen liquid
分子量 ~55.8 kDa
包装pkg of 10 μg
浓度300 μg/mL
颜色clear colorless
NCBI登记号NM_007121
UniProt登记号P55055
运输dry ice
储存温度−70℃
Gene Informationhuman ... NR1H2(7376)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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