产品介绍：
产品说明
包装
5, 25 mg in glass bottle
生化/生理作用
LRE1 is a selective allosteric inhibitor of soluble adenylyl cyclase (sAC), a ubiquitously expressed, essential component of cAMP-signaling. In contrast to G-protein-regulated transmembrane adenylyl cyclase, soluble adenylyl cyclase is directly activated by calcium and carbonate, and is dispersed throughout the cell cytoplasm. LRE1 was found to bind to the bicarbonate activator binding site. It inhibited cAMP accumulation in 4-4 cells with an IC50 of 11 μM, similar to that of KH7 and without its cellular toxicity.
基本信息
| 经验(实验)分子式 | C12H13ClN4S |
| 分子量 | 280.78 |
| MDL编号 | MFCD23148480 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 10 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=CC(N(C2CC2)CC3=CC=CS3)=NC(N)=N1 |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
