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linear di-ubiquitin human

品牌
Sigma-Aldrich
货号
SRP6143
包装型号
规格纯度
参考价格
4096.1 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A wide range of cellular processes are modulated through the generation and attachment of polyubiquitin (polyUb) chains to target proteins. Increasing evidence suggests that polyUb chains joined through linear peptide bonds between the C-terminus of a ubiquitin and the N-terminus of another play important functional roles. The enzyme machinery responsible for the generation of linear polyUb chains has been termed LUBAC, consisting of HOIL-1L and HOIP. Chains of these type have been determined to have an open conformation, similar to polyUb K63, but with very distinct functional properties. Linear polyUb chains are cleaved by the deubiquitylases CYLD, USP5 (IsoT), USP2 and have been shown to bind to many UBDs including NEMO and Trabin-n (3xnzf). Recombinant linear chains of defined length are expressed in E. coli and purified to homogeneity. Amide linkages join the N- and C-terminus of each ubiquitin molecule to each other. This molecule is HIS-tagged at the N-terminus of the most distal ubiquitin.

外形

In 20 mM Tris-HCl, pH 7.5, 0.15 M NaCl and 1 mM EDTA.

制备说明

Centrifuge the vial prior to opening.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in E. coli
测定≥90% (HPLC)
形式liquid
分子量 18 kDa (His Tagged)
包装pkg of 100 μg
运输dry ice
储存温度−70℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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