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LIFR/CD118 human

品牌
Sigma-Aldrich
货号
SRP6449
规格纯度
recombinant, expressed in HEK 293 cells, ≥96% (SDS-PAGE)
参考价格
3663.81 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Leukemia inhibitory factor receptor also known as LIFR; CD118; FLJ98106; FLJ99923; LIF-R; SJS2; STWS; SWS, is the receptor for leukemia inhibitory factor (LIF). The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS), a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

产品性质

重组expressed in HEK 293 cells
测定≥96% (SDS-PAGE)
形式lyophilized
分子量monomer calculated mol wt 115.5 kDa (This protein is fused with the Fc region of human IgG1 at the CT.)
observed mol wt 135-150 kDa by SDS-PAGE (reducing)
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P42702
运输wet ice
储存温度−20℃
Gene Informationhuman ... LIFR(3977)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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