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LDC000067 hydrochloride

品牌
Sigma-Aldrich
CAS
1073485-20-7
货号
SML2179
规格纯度
≥98% (HPLC)
参考价格
839.66 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

LDC000067 (LDC067) is an ATP-competitive, potent and selective cyclin-dependent kinase 9 (CDK9) inhibitor (IC50 = 44 nM/CDK9-CycT1 vs. 5.51 μM/CDK1-CycB1, 2.44 μM/CDK2-CycA, 9.24 μM/CDK4-CycD1, >10 μM/CDK6-CycD3 & CDK7-CycH-MAT1; Kd = 32.7 nM/CDK9-CycT1 vs. 1.01 μM/CDK2-CycA, 16.0 μM/CDK7-CycH-MAT1) with much reduced or little potency against a panel of 28 non-CDK kinases. LDC067 selectively inhibits cellular RNA polymerase II CTD Ser2 phosphorylation (by 40% in HeLa; 60-min, 10 μM LDC067), but not CDK9-independent pSer5 or pSer7, causing apoptosis induction (by 239% and 200% of untreated control in A549 and MCF7 cultures) as a result of blocking RNAPII-mediated mRNA synthesis.

基本信息

经验(实验)分子式C18H18N4O3S · xHCl
分子量370.43 (free base basis)
MDL编号MFCD28137788
NACRESNA.77

产品性质

测定≥98% (HPLC)
形式powder
储存条件protect from light
颜色 white to beige
溶解性DMSO: 2 mg/mL, clear (warmed)
储存温度−20℃
SMILES stringO=S(CC1=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=CC=C1)(N)=O

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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