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KRAS (Mature Form), Active

品牌
Sigma-Aldrich
货号
SRP0722
规格纯度
PRECISIO® Kinase, recombinant
参考价格
3379.69 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Useful for enzyme assay and Western blot.

生化/生理作用

Recombinant human KRAS (2-186) was expressed in E.coli cells using an N-terminal His tag. The RAS gene superfamily encodes a group of closely related 21,000 dalton (p21) proteins with special affinity for guanine nucleotides (GTP). RAS and several other cellular proteins with similar biochemical properties are collectively known as G-proteins and they play key roles in a wide variety of cellular activities, including cell growth, differentiation, secretion, and protein trafficking (1). There are three forms of RAS gene in cells termed H-RAS, N-RAS, and K-RAS. RAS proteins play a direct causal role in human cancer and in other diseases. Mutant H-RAS, N-RAS, and K-RAS occur in varying frequencies in different tumor types (2). Other members of the RAS superfamily may also contribute to cancer.

重悬

Formulated in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

产品性质

重组expressed in E. coli
测定70-95% (SDS-PAGE)
形式frozen liquid
specific activity2.0-3.5 nmol/min·mg (GTPase-Glo)
分子量 ~23 kDa
浓度0.1 μg/μL
登记号NM_033360
运输dry ice
储存温度−70℃
Gene Informationhuman ... KRAS(3845)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H360D
预防措施声明P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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