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KITLG/SCF from mouse

品牌
Sigma-Aldrich
货号
SRP6488
规格纯度
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
参考价格
8058.37 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Kit ligand (KITLG) also known as stem cell factor (SCF), mast cell growth factor (MGF), steel factor (SF), which belongs to the SCF family, and is a widely expressed 28 - 40 kDa type I transmembrane glycoprotein. KITLG is the ligand for the receptor-type protein-tyrosine kinase KIT. SCF / MGF plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG / SCF binding can activate several signaling pathways. KITLG / SF Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG / SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG / SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG / SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1, 4, 5 - triphosphate. KITLG / SCF acts synergistically with other cytokines, probably interleukins.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源mouse
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥98% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 19.1 kDa
observed mol wt 19-30 kDa (DTT-reduced. Lys 26 is the predicted N-terminal.)
包装pkg of 100 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P20826
运输wet ice
储存温度−20℃
Gene Informationmouse ... KITLG(17311)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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