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IL-1 RII/CD121b human

品牌
Sigma-Aldrich
货号
SRP6400
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
参考价格
3487.6 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Interleukin-1 receptor type 2 (IL1R2) also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
标签6-His tagged (C-terminus)
测定≥95% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 38.6 kDa
observed mol wt 50-55 kDa (DTT-reduced. Protein migrates due to glycosylation. Thr 14 is the predicted N-terminus.)
包装pkg of 10 and 50 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P27930
运输wet ice
储存温度−20℃
Gene Informationhuman ... IL1R2(7850)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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