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ICAM1/CD54 human

品牌
Sigma-Aldrich
货号
SRP6491
规格纯度
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
参考价格
13205.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Inter-Cellular Adhesion Molecule 1 (ICAM-1), also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

外形

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量calculated mol wt 75.7 kDa (This protein is fused with Fc fragment of human IgG1 at the C-terminus.)
observed mol wt 100-110 kDa by SDS-PAGE (reducing) (Gln 27 is the predicted N-terminal.)
包装pkg of 20 and 100 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号P05362
运输wet ice
储存温度−20℃
Gene Informationhuman ... ICAM1(3383)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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