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HVEM/TNFRSF14 human

品牌
Sigma-Aldrich
货号
SRP6471
规格纯度
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
参考价格
3288.35 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Herpesvirus entry mediator (HVEM), also known as TNFRSF14, TR2 (TNF receptor like molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFβ (lymphotoxin α) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTβR, the receptor for lymphotoxin αβ heterotrimer. The role of the HVEM LIGHT /LTβ receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

外形

Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.0. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in HEK 293 cells
测定≥95% (SDS-PAGE)
形式lyophilized
分子量monomer observed mol wt 50-60 kDa by SDS-PAGE (reducing) (DTT-reduced.)
calculated mol wt 45.4 kDa (This protein is a disulfide-linked homodimeric protein after removal of the signal peptide. The 413 aa reduced monomer is fused at the C-terminus to human IgG1 (rhHVEM-Fc).)
包装pkg of 20 and 100 μg
杂质<1 EU/μg endotoxin (LAL test)
UniProt登记号Q92956
运输wet ice
储存温度−20℃
Gene Informationhuman ... TNFRSF14(8764)

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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