产品说明
一般描述
The Human MMP-1 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human MMP-1 cell lysate and tissue lysate.
免疫原
Recombinant Human MMP1
应用
请参考Protocol了解详情。
生化/生理作用
Matrix metalloproteinases (MMPs) enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular diseases, skeletal growth-plate disorders, and cancer metastasis. MMP-1 is a secreted collagenase with specificity toward Type I, II, III, VII, and X collagens, aggrecan, serpins, and α2-macroglobulin. It is overexpressed in lumbar intervertebral disc degeneration (IDD). It might also be associated with rheumatoid arthritis and osteoarthritis. MMP-1 is linked with juvenile idiopathic arthritis. Genetic variations in MMP-1 can affect the susceptibility and severity of this disease. MMP-1 might facilitate fibrous plaque disruption via degradation of interstitial collagens and thinning of the fibrous cap.
其他说明
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
基本信息
NACRES | NA.32 |
产品性质
species reactivity | human |
包装 | kit of 96 wells (12 strips x 8 wells) |
technique(s) | ELISA: suitable capture ELISA: suitable |
input | sample type cell lysate sample type tissue lysate |
assay range | inter-assay cv: <12% intra-assay cv: <10% sensitivity: 8 pg/mL standard curve range: 24.69-18000 pg/mL |
detection method | colorimetric |
运输 | wet ice |
储存温度 | −20℃ |
Gene Information | human ... MMP1(4312) |
组份列表
组份可单独销售
货号 | 组份 |
RABDIL6 | ELISA 5X Sample Diluent Buffer (Item D2) |
RABELADE | ELISA 5X Assay/Sample Diluent Buffer E (Item E2) |
RABLYSIS1 | 2X Cell Lysis Buffer (Item J) |
RABSTOP3 | ELISA Stop Solution (Item I) |
RABTMB3 | ELISA Colorimetric TMB Reagent (HRP Substrate, Item H) |
RABWASH4 | 20X Wash Buffer (Item B) |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H290 |
预防措施声明 | P234 - P390 |
危险分类 | Met. Corr. 1 |
储存分类代码 | 8A - Combustible, corrosive hazardous materials |
WGK | WGK 3 |