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HPK1, active, GST tagged human

品牌
Sigma-Aldrich
CAS
182762-12-5
货号
SRP5284
规格纯度
PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
参考价格
6468.88 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Hematopoietic progenitor kinase 1 (HPK1) belongs to the Ste20 serine/threonine kinase superfamily. It comprises a C-terminal citron homology (CNH) domain and a total of 13 tyrosines as potential phosphorylation residues. The HPK1 gene is mapped to human chromosome 19q13.

生化/生理作用

Hematopoietic progenitor kinase 1 (HPK1) acts as a tissue-specific upstream activator for the stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) signaling pathway. By phosphorylating SH2 domain-containing leukocyte protein of 76 kDa (SLP-76), HPK1 effectively blocks the T cell receptor (TCR) signaling. HPK1 is implicated in the inflammatory response and in the pathogenesis of systemic lupus erythematosus (SLE). It mediates the degradation of IκB and nuclear factor-κB (NF-κB) activation by activating inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRESNA.32

产品性质

生物来源human
重组expressed in baculovirus infected Sf9 cells
产品线PRECISIO®
测定≥70% (SDS-PAGE)
形式buffered aqueous glycerol solution
specific activity106-166 nmol/min·mg
分子量 ~65 kDa
NCBI登记号NM_007181
application(s)cell analysis
运输dry ice
储存温度−70℃
Gene Informationhuman ... MAP4K1(11184)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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